I get a crash during launch through MO on freshly installed Skyrim and SPM 4.4.
Also, I can not launch any program that is on the MO upper toolbar, it just says "MO is locked..." and then nothing happens, and this message disappears. Everything installed on X:\Skyrim, actually, followed Install Guide precisely, installed all redistributables, etc. Tried to disable all mods in MO, launch of SKSE nor any app from toolbar still doesn't work. Also made all *.exe files to run as Admin in Skyrim folder.
Though, I can launch skse_loader.exe directly through explorer and it loads to main menu, but new game does not allow me to create a character or anything, just shows me view to the map from some nice looking spot. I can load pre-configured saves though, this lets me play but I get some errors on start and an error about LODs very frequently when I move the character or rotate the camera. And I guess that not all the mods are loaded.
To me this looks like some weird problem with MO. Can't find any logs other than mo_interface.log:
Additional info: Screenshots
i7-3820 4.1GHz (overclocked)
ATI Radeon HD 7950 / R9 280 3Gb VRAM
12 Gb Ram 1600 MHz DDR3
SSD for Windows, HDD Sata 2 for Skyrim.