Happens to me also, OneTweak comes with the 4.4 package which is supposed to help with this...I'm not sure if it is configured via it's ini yet though. Google OneTweak nexus and have a read through. Might find your answer there.
Alternatively.... alt-tab out, do what you gotta do, alt-tab in and then alt-tab in again...then let it load up again. Takes a good 30 seconds on my rig.